Selected Publications

Names of current and former members of the Sancak Lab are bolded

  • Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex 1 impairment

Nature Communications, 2022

Balderas, E., Eberhardt, D. R., Lee, S., Pleinis, J. M., Sommakia, S., Balynas, A. M., Yin, X., Parker, M. C., Maguire, C. T., Cho, S., Szulik, M. W., Bakhtina, A., Bia, R. D., Friederich, M. W., Locke, T. M., Van Hove, J., Drakos, S. G., Sancak, Y., Tristani-Firouzi, M., Franklin, S., … Chaudhuri, D. (2022). Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment. Nature communications, 13(1), 2769. https://doi.org/10.1038/s41467-022-30236-4

  • Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

Life Science Alliance, 2020

MacEwen M.J., Markhard A.L., Bozbeyoglu M., Bradford F., Goldberger O., Mootha V.K., Sancak Y. (2020). Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. Life Sci Alliance. 2020;3(10):e202000718. Published 2020 Aug 7. doi:10.26508/lsa.202000718

  • MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+

Proceedings of the National Academy of Sciences of the United States of America, 2018

Kamer K.J., Sancak Y., Fomina Y., Meisel J.D., Chaudhuri D., Grabarek Z., Mootha V.K. (2018). MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. Proceedings of the National Academy of Sciences of the United States of America. 115(34): E7960-E7969.

  • Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

Proceedings of the National Academy of Sciences of the United States of America, 2017

Bick, A.G., Wakimoto, H., Kamer, K.J., Sancak, Y., Goldberger, O., Axelsson, A., DeLaughter, D.M., Gorham, J.M., Mootha, V.K., Seidman, J.G., Seidman, C.E. (2017). Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proceedings of the National Academy of Sciences of the United States of America. 114 (43): E9096-E9104

  • Architecture of the mitochondrial calcium uniporter

Nature, 2016

Oxenoid. K., Dong, Y., Cao, C., Cui, T., Sancak, Y., Markhard, A.L., Grabarek, Z., Kong, L., Liu, Z., Ouyang, B., Cong, Y., Mootha, V.K., Chou, J.J. (2016). Architecture of the mitochondrial calcium uniporter. Nature. 533: 269-273.

  • Reconstitution of the mitochondrial calcium uniporter in yeast

Proceedings of the National Academy of Sciences of the United States of America, 2014

Kovacs-Bogdan, E., Sancak, Y., Kamer, K. J., Plovanich, M., Jambhekar, A., Huber, R. J., Myre, M. A., Blower, M. D., Mootha, V. K. (2014). Reconstitution of the mitochondrial calcium uniporter in yeast. Proceedings of the National Academy of Sciences of the United States of America. 111(24):8985-90

  • The uniporter: from newly identified parts to function

Biochemical and biophysical research communications, 2014

Kamer, K.J., Sancak, Y., and Mootha, V.K. (2014). The uniporter: from newly identified parts to function. Biochemical and biophysical research communications. 449(4): 370-2

  • EMRE is an essential component of the mitochondrial calcium uniporter complex

Science, 2013

Sancak, Y., Markhard, A.L., Kitami, T., Kovacs-Bogdan, E., Kamer, K.J., Udeshi, N.D., Carr, S.A., Chaudhuri, D., Clapham, D.E., Li, A.A., Calvo, S. E., Goldberger, O., Mootha, V. K. (2013). EMRE is an essential component of the mitochondrial calcium uniporter complex. Science 342: 1379-1382.

  • MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

PLoS One, 2013

Plovanich, M., Bogorad, R.L., Sancak, Y., Kamer, K.J., Strittmatter, L., Li, A.A., Girgis, H.S., Kuchimanchi, S., De Groot, J., Speciner, L., Taneja, N., Oshea, J., Koteliansky, V., Mootha, V. K. (2013). MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One 8: e55785

  • MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2)(+) uniporter

Cell Metabolism, 2014

Csordas, G., Golenar, T., Seifert, E.L., Kamer, K.J., Sancak, Y., Perocchi, F., Moffat, C., Weaver, D., de la Fuente Perez, S., Bogorad, R., Koteliansky, V., Adijanto, J., Mootha, V. K., Hajnoczky, G. (2013). MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca(2)(+) uniporter. Cell Metab 17: 976-987

  • MCU encodes the pore conducting mitochondrial calcium currents

Elife, 2013

Chaudhuri, D., Sancak, Y., Mootha, V.K., and Clapham, D.E. (2013). MCU encodes the pore conducting mitochondrial calcium currents. Elife 2: e00704

  • Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Nature, 2011

Baughman, J.M., Perocchi, F., Girgis, H.S., Plovanich, M., Belcher-Timme, C.A., Sancak, Y., Bao, X.R., Strittmatter, L., Goldberger, O., Bogorad, R.L., Koteliansky, V., Mootha, V. K. (2011). Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 476 (7360): 341-5